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Lab tests show that THC-O can be 300 percent stronger than regular THC. However, THC-O is not water soluble, therefore less THC makes it into your bloodstream. But because of its potency, even a few molecules that make it through will have you feeling the full force of THC-O. This results in a slower onset of effects; you’ll have to wait 30 to 60 minutes before you feel the effects of THC-O. This is because your body must separate (digest) the acetate molecule from the THC molecule before it’s sent to your brain, the good news is it can stimulate the cannabinoid receptors in your brain in a way that regular THC can’t.